Dermatology Innovations
Deep Dive
The Hormone DHT: Understanding Its Role in Hair Loss
Uncover how DHT sensitivity, not just hormone levels, drives pattern baldness in men and women.
Source: J Clin Endocrinol MetabPublished on: March 12, 2024
Abstract in Plain English
Dihydrotestosterone (DHT) is a natural derivative of testosterone linked to androgenetic alopecia. This study analyzed how DHT alters follicle sensitivity rather than simply reducing hormone levels.
Key Findings
- DHT binds to androgen receptors in follicles, shortening the growth phase.
- Genetic variants in the AR gene increase follicle sensitivity.
- Blocking DHT with finasteride can slow progression in 60–70% of cases.
- Local inflammation accompanies androgen receptor activation.
Why It Matters
Understanding DHT helps debunk myths about testosterone. It’s not hormone quantity, but receptor sensitivity that drives pattern hair loss.
Study Limitations
Most data come from male cohorts; future studies aim to clarify effects in women.
Citation & Review Team
Full Citation
Price VH et al., J Clin Endocrinol Metab, 2022.Review Team
Author: Student Editor
Fact-Checker: Dermatology Researcher
Disclaimer
This article is for educational purposes only and not a substitute for professional medical advice.