Clinical & Therapeutic Research
Deep Dive
Finasteride vs. Dutasteride: Comparing the Two DHT Blockers
Compare how two major DHT-blocking drugs differ in mechanism, efficacy, and side effects.
Source: J Clin Endocrinol MetabPublished on: December 6, 2024
Abstract in Plain English
Finasteride and Dutasteride are two of the most commonly prescribed drugs for androgenetic alopecia. A multicenter clinical trial in The Journal of Clinical Endocrinology & Metabolism (2024) compared their long-term outcomes.
Key Findings
- Dutasteride reduced scalp DHT levels by 90%, compared to 70% with Finasteride.
- Both drugs slowed hair loss, but Dutasteride produced thicker regrowth after 12 months.
- Side effects were rare but more frequent with higher DHT suppression.
- Combination with topical Minoxidil improved satisfaction scores by 30%.
Why It Matters
This study clarifies the nuanced differences between two similar medications and supports tailored prescribing based on patient tolerance and hormonal profiles.
Study Limitations
The study population was limited to men aged 25-50.
Citation & Review Team
Full Citation
Hernandez L. et al., J Clin Endocrinol Metab, 2024.Review Team
Author: Student Editor
Fact-Checker: Dermatology Researcher
Disclaimer
This article is for educational purposes only and not a substitute for professional medical advice.