Molecular & Cellular Biology
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Keratin Genes: How Mutations Alter Hair Texture and Strength
Discover how variations in keratin genes shape hair structure, texture, and resistance to damage.
Source: J Invest DermatolPublished on: September 27, 2024
Abstract in Plain English
Keratin proteins form the structural backbone of hair fibers. A genomic mapping project published in The Journal of Investigative Dermatology (2024) identified how mutations in keratin genes (KRT71, KRT85, KRT86) affect texture and strength.
Key Findings
- Mutations in KRT71 lead to curly or fragile hair phenotypes.
- Environmental stress can alter keratin gene expression through oxidative pathways.
- Balanced sulfur crosslinking determines elasticity and shine.
- Novel treatments aim to stabilize keratin bonds without chemical damage.
Why It Matters
By decoding keratin genetics, scientists can design gentler hair treatments and biomaterials that mimic healthy structural proteins.
Study Limitations
This study focused on genetic factors and did not include external hair care practices.
Citation & Review Team
Full Citation
Nguyen A. et al., J Invest Dermatol, 2024.Review Team
Author: Student Editor
Fact-Checker: Dermatology Researcher
Disclaimer
This article is for educational purposes only and not a substitute for professional medical advice.